The eighth-year veteran, who is tied for the league lead with three receiving touchdowns, has 12 receptions for 130 yards (10.8 avg.) in all through two games this season.
Atlanta will host an Indianapolis squad that is also coming off of a victory in Week 2, taking down the Tennessee Titans 19-17 in Tennessee.
Ryan hooked up with Julio Jones on a 14-yard pass to get the Falcons within 27-24, but never got a chance to force a tie or take the lead.
The Indianapolis Colts (2-1) defeated the Atlanta Falcons (1-2) in their home opener on Sunday, 27-24, at Lucas Oil Stadium. Hilton returned to the sideline without his helmet and gloves with about 11 minutes left in the third quarter.
Indianapolis Colts quarterback Jacoby Brissett opened the game by completing his first 16 passes, including one for a touchdown, before throwing an incompletion on second-and-goal from the Atlanta 3-yard line.
He threw the ball away to avoid a sack on the next play, too, setting up Adam Vinatieri for a 21-yard field goal to give the Colts a 13-0 lead. Ryan now has 4,143 completions and 303 touchdown passes. The league's third-leading rusher entering Week 3 action, Mack could be spelled by a mixture of second-year backs Nyheim Hines and Jordan Wilkins if he's unable to go or limited Sunday against the Falcons.
After missing five of his first eight kicks and dealing with two weeks of questions, 46-year-old Adam Vinatieri reverted to his traditional form.
