Corbyn has also been criticized for the party's delay in fully adopting the International Holocaust Remembrance Alliance's definition of anti-semitism.
Mr Mirvis, the Chief Rabbi of the United Hebrew Congregations of the Commonwealth, warned that "the very soul of our nation is at stake" in the general election on December 12.
Chief Rabbi Ephraim Mirvis attacked Jeremy Corbyn's Labour Party, suggesting voters should avoid casting a ballot for the main opposition in the U.K.'s December 12 general election because of antisemitism "sanctioned from the top".
He said Corbyn's assertion during an ITV debate that Labour had investigated all outstanding cases was a "mendacious fiction", before asking: "What will become of Jews and Judaism in Britain if the Labour Party forms the next government?"
During the election campaign, Welsh Labour candidate Maria Carroll has had to explain her membership of a Facebook group offering help to party members facing anti-Semitism investigations, as well as other disciplinary matters. Our racial and religious manifesto defines our policies to achieve this.
Mirvis said Jewish people had expressed "justified" concern about anti-Semitism in the Labor Party.
Instead it was left to the Labour peer Lord Dubs - who came to Britain in the 1930s as a child refugee fleeing the Nazis - to say he believed the attack had been "unjustified and unfair".
His comments were seized on by Boris Johnson who said Mr Corbyn's inability to stamp out the "virus" of anti-Semitism in Labour represented a "failure of leadership".
Chief Rabbi Ephraim Mirvis, in an article in The Times newspaper, questioned how complicit in prejudice an opposition leader would have to be to be considered unfit for office.
He was backed by the Archbishop of Canterbury, the Most Rev Justin Welby, who said his intervention reflected the alarm felt by many in the Jewish community.
"British Jews are acutely anxious about the proliferation of anti-Semitism in the official party of opposition".
"The reason I have left the Labour Party is because I can not ask people to vote for Jeremy Corbyn as Prime Minister while we have a Labour Party that is institutionally anti-Semitic", she told BBC Radio 4's The World at One.
Labour issued a statement saying Corbyn is a "lifelong campaigner against antisemitism and has made absolutely clear it has no place in our party and society".
"Two out of our current four Labour MPs for Leeds are Jewish: the MP for North East Leeds, Fabian Hamilton, is the shadow minister for peace and worldwide relations and the MP for North West Leeds, Alex Sobel, has a proud record of promoting of co-operative relationships and enterprise".
"It's an unprecedented intervention in a general election", Conservative Cabinet minister Michael Gove told Talk Radio on Tuesday.
Asked if the Chief Rabbi's comments would undermine this, Mr McDonnell replied: "No, I don't think so".
'A Labour government will guarantee the security of the Jewish community, defend and support the Jewish way of life, and combat rising anti-Semitism in our country and across Europe.
