Blood Test May Detect Alzheimer's 16 Years in Advance

Blood Test May Detect Alzheimer's 16 Years in Advance

This same bacteria causes periodontal disease which creates gum infection and potential tooth loss when left untreated.

The scientists looked at patterns of neuropsychological deficits, vascular risk factors and neuropathological differences between the Hispanic and non-Hispanic patients, who were matched by age, education, global mental status and severity of functional decline at first diagnosis.

The findings come together to show that changes in NfL levels were an accurate predictor of how brain damage develops, according to the study. When these cells start to die in Alzheimer's disease, traumatic brain injury or other neurodegenerative diseases, this building block is released into the blood stream.

The researchers say they have also begun "new drug application-enabling studies" with the gingipain-inhibiting substance tested here.

However, there was also good news. After injections, the mice showed a decrease in brain neurodegeneration.

A drug developed by the company, COR38, is now in human trials.

A 2017 study out of Taiwan found that people with chronic gum disease lasting 10 years had a 70 percent increased risk for developing Alzheimer's.

An incredible discovery by medical researchers could change the treatment of Alzheimer's disease as we know it, now that a simple blood test could identify the condition over a decade before it sets in.

The findings are reported in Science Advances. The bacteria was found in three brain tissue DNA samples.

'Our brains need time to recover from the stresses of the day. So many efforts to treat Alzheimer's by moderating these proteins have failed that the hypothesis has been seriously questioned. This, says Lynch, shows P. gingivalis is a cause of Alzheimer's, not a result. Since the study's publication, the neurologists are planning to expand their research to include more patients. It also seemed to improve participants with Alzheimer's.

Bacteria involved in gum disease and other illnesses have been found after death in the brains of people who had Alzheimer's, but until now, it hasn't been clear whether these bacteria caused the disease or simply got in via brain damage caused by the condition.

Tests on mice confirmed the bacteria could travel from the mouth to the brain and showed the toxic protein they secrete, called gingipain, destroyed brain neurons. 'A couple of years ago it was suggested [amyloid] accumulation might actually be part of the brain's innate immune system for dealing with bacteria, ' he says.

P. gingivalis infection was thought to fuel high levels of beta- amyloid that eventually became toxic.

Antibiotics also worked similarly well, but less effectively.

Now, researchers at Cortexyme, an American pharmaceutical corporation who has invested heavily in gum disease research, add even more weight to the gum disease-Alzheimer's association. "High levels could be a sign of many different neurological diseases and injuries".

The BDA claims this study highlights the fact that oral health can't remain an "optional extra" in the health service.

Researchers found gingipains in 91% and 96% (for each of the 2 protein types) of brain tissue samples from people with Alzheimer's disease compared to 39% and 52% of brain samples from people without Alzheimer's disease.

A recent study has linked gum infection to Alzheimer's disease.

"It's important to pursue that as there hasn't been a new drug for dementia in 15 years". The drug is now being tested in clinical studies.

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